Application of 39581-21-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39581-21-0 name is N-Butyl-2-cyano-acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture ofan aromatic aldehyde 1a-1f (1 mmol) with N-butyl-2-cyanoacetamide 2 (1 mmol) in ethanol (5 mL) wasrefluxed for 2 h, after which phthalhydrazide 3(1 mmol) was added to the mixture and refluxingcontinued for 3 h more. Upon completion of theprocess, according to TLC, the mixture was cooled toroom temperature and the precipitate was filtered off.The crude product was crystallized from ethanol togive the respective compound 4a-4f.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Butyl-2-cyano-acetamide, and friends who are interested can also refer to it.
Reference:
Article; Elmi-Mehr; Davoodnia; Pordel; Russian Journal of General Chemistry; vol. 88; 12; (2018); p. 2595 – 2600;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts