Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, A new synthetic method of this compound is introduced below., Quality Control of 3-(4-Fluorophenyl)-3-oxopropanenitrile
General procedure: 4.2.1. Method (A) A mixture of 3 (1.18 g, 5 mmol), beta-ketonitrile (5 mmol) and 4-anisaldehyde (0.68 g, 5 mmol) in acetic acid (20 ml) and in the presence of TEA (1 ml) was heated under reflux for 4 h. The reaction mixture was poured into crushed ice (20 ml) and the solid obtained was collected by filtration, washed with water (3 × 10 ml) and recrystallized from ethanol to give pure 4. 4.2.2. Method (B) The procedure was similar to that described in Method A except that the mixture was capped in closed vessels and irradiated in a microwave oven at 150 C for 15 min using Synthos 3000 (500 W). The reaction was worked and the solid obtained was recrystallized from ethanol to give 4.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; El-Borai; Rizk; Abd-Aal; El-Deeb; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 92 – 96;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts