In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1735-53-1, name is 4-Bromo-3-(trifluoromethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H3BrF3N
Description 24; 2′-fluoro-2-(trifluoromethyl)-4-biphenylcarboxylic acid (D24); To 4-bromo-3-trifluoromethylbenzonitrile (1.5 g, 6.0 mmol) and 2-fluorophenylbenzoic acid (1.0 g, 7.2 mmol) under a flush of argon was added toluene (30 ml_), saturated aqueous sodium carbonate (10 ml.) and ethanol (10 ml.) before addition of palladium tetrakistriphenylphosphine (345 mg, 0.3 mmol). The mixture was heated to 90 0C (block temperature) for 19 h. The reaction mixture was partitioned between ethyl acetate (100 ml) and water (80 ml_). The organic phase was washed with brine (80 ml.) before it was dried (phase separator) and concentrated in vacuo. The residue was purified by silica chromatography, eluting 0-75 % EtOAc in hexane. The resulting product was then dissolved in ethanol (40 ml.) and water (10 ml.) and potassium hydroxide (2.5 g, 44 mmol) was added. The solution was heated overnight to 90 0C (block temperature). The reaction mixture was concentrated and partitioned between ethyl acetate (70 ml.) and 2M HCI (30 ml_). The organic phase was washed with further 2M HCI (30 ml.) before it was dried (phase separator) and the solvent removed in vacuo. The crude product was purified by reverse phase chromatography, eluting 5-100 % acetonitrile in water to give the title compound as a solid (551 mg, 1.94 mmol). MS (ES”): C14H8F4O2 requires 284; found 283 (M-H+).
The synthetic route of 1735-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/74820; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts