Introduction of a new synthetic route about C8H6ClNO

According to the analysis of related databases, 3598-13-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3598-13-8, name is 2-(4-Chlorophenoxy)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

Starting Material 6: (5-Nitro-2-phenyl-benzothiazole4-yl)-acetonitrile STR23 5-Nitro-2-phenyl-benzothiazole (1.52 g, 5.94 mmol)(Starting Material 1) and 4-chlorophenoxyacetonitrile (1.05 g, 6.26 mmol) (Aldrich) were mixed in dimethylsulfoxide (20 mL). Powdered potassium hydroxide (1.40 g, 25 mmol) was added, and the mixture was stirred at room temperature for 8 hours. The mixture was poured into ice water and acidified with concentrated hydrochloric acid. The mixture was extracted with ethyl acetate (3*). The combined organic layers were washed with water (2*), brine and dried over anhydrous magnesium sulfate. The solvent was concentrated in vacuo and the residue was crystallized from ethyl acetate/hexanes to give the product. (Yield 0.64 g, 37%).

According to the analysis of related databases, 3598-13-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; US6153634; (2000); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts