Related Products of 63069-50-1, The chemical industry reduces the impact on the environment during synthesis 63069-50-1, name is 4-Amino-3-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.
To a solution of 4-amino-3-fluoro-benzonitrile (5.0 g, 36.7 mmol) in ethanol (61 mL) was added a hydroxylamine hydrochloride solution (5.16 g, 73.5 mmol) in 50 mL of water followed by potassium carbonate (8.12 g, 58.8 mmol) in 75 mL of water. To the cloudy solution was then introduced quinolin15 8-01 (0.07 g, 0.48 mmol). The reaction mixture was stirred for 5 hours at 100C. The reaction mixturewas then cooled to 25C, the ethanol was removed under reduced pressure, and the resulting mixture was then extracted with ethyl acetate. The total combined organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to give 5.83 g of 4-amino-3- fluoro-N-hydroxy-benzamidine as a yellow solid. The crude residue was used in the following stepwithout further purification. LC/MS (Method A) retention time = 0.20 mm; 166 [M+H].(brs, 2H).1H NMR (400 MHz, CDCI3) oe ppm: 9.30 (s, 1H), 7.25 (m, 2H), 6.70 (t, 1H), 5.60 (brs, 2H), 5.30
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; HOFFMAN, Thomas, James; STIERLI, Daniel; BEAUDEGNIES, Renaud; POULIOT, Martin; (65 pag.)WO2018/15458; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts