These common heterocyclic compound, 123-06-8, name is Ethoxymethylenemalononitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
To a stirred (m)ethanolic solution (only 5b in methanol) of hydrazine hydrate (17.2 mmol) was added enol ether 3a-d (17.2 mmol) dropwise at rt. The reaction mixture was heated under reflux for 1-1.5 h. After cooling the crude product was filtered and recrystallized from the appropriate solvent or purified by column chromatography.
The synthetic route of Ethoxymethylenemalononitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tarabova, Denisa; Soralova, Stanislava; Breza, Martin; Fronc, Marek; Holzer, Wolfgang; Milata, Viktor; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 752 – 760;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts