Application of 5414-21-1, The chemical industry reduces the impact on the environment during synthesis 5414-21-1, name is 5-Bromovaleronitrile, I believe this compound will play a more active role in future production and life.
General procedure: To synthesize compound 1, 2-(1H-indol-3-yl)acetic acid (3.5 g, 20 mmol) was added to a stirred suspension of NaH (4 g, 100 mmol, mixture of 60% NaH in mineral oil) in THF (80 mL) at 0C. The resulting mixture was stirred for 30 min followed by dropwise addition of ethyl iodide (5 mL, 60 mmol) in THF (30 mL), allowed to warm to room temperature (RT), and stirred overnight. The reaction mixture was then cooled to 0 C and quenched by addition of 10 mL MeOH and 20 mL H2O followed by extraction with Et2O (2 × 100 mL). The aqueous layer was acidified by addition of 6N hydrochloric acid (30 mL) and extracted with ethyl acetate (EtOAc, 2 × 100 mL). The combined organic extracts were washed with H2O (2 × 100 mL) and brine (2 × 100 mL), dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by flash chromatography (1:3 EtOAc petroleum ether, v/v) to yield 2-(1-ethyl-1H-indol-3-yl)acetic acid (1) as a colorless solid (3.87 g, 95% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromovaleronitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Li, Xia; Ma, Hongguang; Li, Lin; Chen, Yifan; Sun, Xiao; Dong, Zizheng; Liu, Jing-Yuan; Zhu, Weiming; Zhang, Jian-Ting; Oncogene; vol. 37; 18; (2018); p. 2469 – 2480;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts