Synthetic Route of 2338-75-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2338-75-2, name is 4-(Trifluoromethyl)phenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.
Compound 3 (1.00 g, 1.65 mmol) and 2-(4-(trifiluoromethyl)phenyl)acetonitrile (0.76 g, 4.10 mmol) were addedinto dry ethanol (50 mL) and dry THF (10 mL), and then CH3ONa(0.22 g, 4.08 mmol) was added quickly. The mixture was refluxed for 6 hunder an atmosphere of nitrogen. When the reaction was finished, themixture was cooled to room temperature. Then the resulting precipitatewas collected by filtration, and dried under vacuum. The crude productwas purified by column chromatography (silica gel, CH2Cl2/petroleumether, v/v 2/3), affording a bright orange solid (1.12 g). Yield 72%.Mp: 310-312 C. 1H NMR (400 MHz, CDCl3) 8.36 (s, 2H), 7.77 (d,J 4.4 Hz, 6H), 7.67 (d, J 8.0 Hz, 4H), 7.58 (s, 2H), 7.41 (t, J 7.6 Hz,J 7.2 Hz, 4H), 7.26 (d, J 7.6 Hz, 2H), 7.13 (d, J 8.4 Hz, 2H), 7.07(d, J 8.0 Hz, 2H), 7.02 (t, J 7.6 Hz, J 7.2 Hz, 2H), 4.15-4.10 (m,4H), 1.50 (t, J 9.2 Hz, J 7.2 Hz, 18H) (Figs. S9 and S10); 13C NMR(100 MHz, CDCl3) 143.95, 141.29, 140.51, 139.68, 137.35, 133.05,132.43, 131.84, 130.39, 130.11, 128.48, 127.04, 126.87, 126.27,126.12, 126.09, 124.74, 120.91, 117.70, 112.56, 112.01, 40.50, 36.21,29.30, 26.92, 11.81 (Fig. S11). IR (KBr, cm 1): 611, 619, 746, 789, 841,863, 951, 997, 1068, 1121, 1138, 1164, 12621326, 1385, 1417, 1452,1467, 1478, 1616, 1637. HRMS (MALDI-TOF) m/z: [M] Calcd forC60H48F6N4 938.3783; Found 938.3769 (Figs. S12 and S13). Anal. Calcd(%) for C60H48F6N4: C 76.74, H 5.15, N 5.97; Found: C 76.82, H 5.26, N5.88.
The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)phenylacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Cheng, Dandan; Xu, Defang; Wang, Ying; Zhou, Hongke; Zhang, Yihao; Liu, Xingliang; Han, Aixia; Zhang, Chao; Dyes and Pigments; vol. 173; (2020);,
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