Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 194853-86-6
Weigh 508mg of 5,5-dimethylhydantoin into eggplant-shaped bottles,Add 5mL DMF with stirring to completely dissolve it.Then add 220mg of K2CO3 (1eq) and stir at 45 C for half an hour.Make them fully mixed, and finally slowly add 4-fluoro-2-trifluoromethylbenzonitrile (300mg) in DMF and stir under heating for 5h. After the reaction is complete, cool to room temperature, add 30mL of ethyl acetate and dilute with 20 mL of saturated ammonium chloride aqueous solution was extracted three times, and saturated brine was extracted once. The organic layer was dried over anhydrous magnesium sulfate for 6 h, filtered with suction, and concentrated. Finally, 200-300 mesh column chromatography was performed to obtain 330 mg of a white solid. Yield 79%.
According to the analysis of related databases, 194853-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhengzhou University; Xu Xia; Liu Hongmin; Ke Yu; Liang Jianjia; Xie Hang; (19 pag.)CN110790750; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts