These common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8Cl4N2
5 g of 3,4,5,6-tetrachlorophthalonitrile, 2.45 g of 2,6-difluorophenol, 3.9 g of K2CO3 and 25 ml of N, N-dimethylformamide were stirred at 100 ml flask and then stirred while heating at 70 °C. When the reaction is complete, EA (ethyl acetate) is used for extraction. After extraction, the resultant was concentrated to obtain a solid. Here, the obtained solid is dissolved in a small amount of dichloromethane and then washed several times with hexane, filtered and dried in vacuo to give 3,4,6-trichloro-5- (2,6-difluoro -phenoxy) -phthalonitrile.
The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sanxing SDI Co., Ltd.; Zheng Yishu; Xu Huiyuan; Xin Mingye; Shen Xianxiong; Zheng Zhouhao; Han Guishi; (48 pag.)CN107522704; (2017); A;,
Nitrile – Wikipedia,
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