In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21423-84-7 as follows. category: nitriles-buliding-blocks
Reference Example 148 Production of ethyl 2-chloro-4-methylbenzoate A mixture of 2-chloro-4-methylbenzonitrile (5.5 g, 36.28 mmol), conc. sulfuric acid (30 mL) and ethanol (30 mL) was heated under reflux for 22 hr. The reaction mixture was ice-cooled, and neutralized with 8N aqueous sodium hydroxide solution, and ethanol was evaporated. The residue was extracted with ethyl acetate, and the extract was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was diluted with ethyl acetate-hexane (1:10, 120 mL). The insoluble material was filtered off, and the filtrate was under reduced pressure and concentrated to give the title compound (3.23 g, 45%) as a pale-brown liquid. 1H NMR (300 MHz, DMSO-d6) delta:1.31 (3 H, t, J = 7.1 Hz), 2.35 (3 H, s), 4.30 (2 H, q, J = 7.1 Hz), 7.26 (1 H, d, J = 7.8 Hz), 7.41 (1 H, s), 7.71 (1 H, d, J = 7.8 Hz).
According to the analysis of related databases, 21423-84-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2471789; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts