6621-59-6, name is 6-Bromohexanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 6621-59-6
6-[5-(1-methyl-2-pyrrolidinyl)-2-pyridinyl]hexanenitrile (6). A stirred mixture of 6-aminonicotine (0.62 g, 3.5 mmol) and NaH (80% in mineral oil, 0.16 g, 5.25 mmol) in dry toluene (20 mL) was refluxed for 2 h and then cooled to room temperature. 6-Bromohexane-nitrile (0.65 g, 3.7 mmol) was added and the reaction was left at ambient temperature over night. The solvent was evaporated and the residue was chromatographed [silica gel, CHCl3/MeOH/NH4OH (18:3:0.1)] to afford 0.40 g (41%) of 6; IR (film): 2270 cm-3 (CN); 1H-NMR (CDCl3, 270 MHz) delta 7.95 (d, J=2.5 Hz, 1H), 7.47 (dd, J=2.5, 8.5 Hz, 1H), 6.39 (d, J=8.5 Hz, 1H), 4.49 (m, 1H), 3.36-3.16 (m, 3H), 2.90 (t, J=9 Hz, 1H), 2.36 (t, J=7 Hz, 2H), 2.29-2.19 (m, 1H), 2.19-2.06 (m, 1H), 2.14 (s, 3H), 2.00-1.50 (m, 9H); 13C NMR (CDCl3, 68 MHz) delta 158.2, 147.4, 136.5, 126.4, 119.4, 106.9, 68.5, 56.7, 41.7, 40.0, 34.3, 28.7, 26.0, 25.0, 22.1, 16.7;
The synthetic route of 6621-59-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Independent Pharmaceutica AB; US6656469; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts