Related Products of 63069-50-1, These common heterocyclic compound, 63069-50-1, name is 4-Amino-3-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 50% aqueous solution of Hydroxylamine (2.18 mL, 33.1 mmol) was added to a 2-propanol (44 mL) solution of 4-amino-3-fluorobenzonitrile (3.00 g, 22.0 mmol) at room temperature, and the mixture was stirred at 70C for 5 hours. After the reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was washed with a hexane-ethyl acetate (4:1, v/v) mixture to give the title compound (3.67 g, yield: 98%). 1H-NMR (500 MHz, DMSO-d6) delta ppm: 9.35 (1H, s), 7.27 (1H, dd, J = 13, 2 Hz), 7.21 (1H, dd, J = 8, 2 Hz), 6.71 (1H, dd, J = 9, 8 Hz), 5.63 (2H, s), 5.33 (2H, s).
The synthetic route of 63069-50-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daiichi Sankyo Company, Limited; YAMANOI, Shigeo; NAMIKI, Hidenori; OCHIAI, Yuichi; HOSHINO, Madoka; MATSUMOTO, Koji; EP2805941; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts