Reference of 1483-54-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1483-54-1 name is 2-Amino-4-(trifluoromethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a 50 mL round bottom flask, a suspension of 2-aminoarylnitriles (10.0 mmol) in ethyl chloroformate(52.0 mmol, 5.0 mL) was refluxing for 6 h. After complete removal of excess ethyl chloroformate in vacuo (by forming azeotrope with toluene), the residue was recrystallized from cyclohexane (for mostsubstrates) to furnish the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-4-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Nguyen, Huy H.; Fettinger, James C.; Haddadin, Makhluf J.; Kurth, Mark J.; Tetrahedron Letters; vol. 56; 40; (2015); p. 5429 – 5433;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts