621-03-4, name is 2-Cyano-N-phenylacetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H8N2O
General procedure: A mixture of beta-keto amide (0.2 mmol), ynal (0.2 mmol) and K2CO3 (30 mol%) in THF (1.0 mL) was placed in a test tube (10 mL) equipped with a magnetic stirring bar. The mixture was stirred at 65 C for 10 h. After the reaction was finished, water (5 mL) was added and the solution was extracted with ethyl acetate (3×5 mL), the combined extract was dried with anhydrous MgSO4. Solvent was removed, and the residue was separated by column chromatography to give the pure sample.
The synthetic route of 621-03-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Zhengwang; Liu, Jiayang; Jin, Caiju; Tan, Qi; Ye, Min; Tetrahedron Letters; vol. 60; 18; (2019); p. 1265 – 1267;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts