Application of 60899-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60899-34-5 name is 1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 1-oxo-2,3-dihydro-JH-indene-4-carbonitrile INT-1 (42.5 g, 0.27 mol) and (R)-2-methylpropane-2-sulfinamide (36.0 g, 0.30 mol) in toluene (530 mL)was added titanium tetraethoxide (84.1 mL, 92.5 g, 0.40 mol) and the reaction mixture was heated at 60C for 12 h under N2. The crude (R)-N-(4-cyano-2,3-dihydro-1H- indene-1-ylidene)-2-methylpropane-2-sulfinamide INT-4 was used directly in the next experiment. LCMS-ESI (m/z) calculated for C14H16N20S: 260.3; found 261.1 [M+H],3.19 mm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Oxo-2,3-dihydro-1H-indene-4-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; CELGENE INTERNATIONAL II SARL; SCOTT, Fiona, Lorraine; MEADOWS, Kristen, R., Taylor; PEACH, Robert; (154 pag.)WO2018/64356; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts