Adding a certain compound to certain chemical reactions, such as: 115661-37-5, name is 2-Amino-3-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115661-37-5, Recommanded Product: 2-Amino-3-fluorobenzonitrile
2-Amino-3-fluorobenzonitrile 45a (1 g, 7.35 mmol, purchased from Shanghai Bide Pharmatech Ltd.) was dissolved in 50 mL of dichloromethane. The reaction solution was added with N-bromosuccinimide (1.37 g, 7.71 mmol), and stirred for 16 hours. The reaction solution was added with water, and extracted with dichloromethane (50 mL×3). The organic phases were combined, washed with saturated sodium chloride solution (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by CombiFlash rapid preparation instrument with elution system B to obtain the title product 45b (1.25 g), yield: 79.13%. MS m/z (ESI):215.0 [M+1].
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Reference:
Patent; Jiangsu Hengrui Medicine Co. Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; LU, Biao; ZHANG, Junzhen; JIN, Fangfang; HE, Feng; TAO, Weikang; EP3569596; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts