Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-64-2, name is 2,5-Difluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H3F2N
Potassium carbonate (2.9Og, 21 mmol) was added to a solution of phenol (791 mg, 8.4mmol) in 30 ml of N,N-dimethylformamide. The reaction mixture was stirred for 15 minutes at room temperature, and then 2,5-difluorobenzonitrile (973mg, 7mmol) was added. The resulting mixture was heated to 1000C for 18 hours, after which time it was allowed to cool to room temperature. It was then concentrated in vacuo. The resulting residue was diluted with ethyl acetate (50ml), and then washed with water (2x100ml) and 1 M sodium hydroxide solution (100ml). The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure to afford the title compound, as a yellow oil, 1.449g, 97%. 1HNMR(400MHz, CDCI3) delta: 6.87(q, 1 H), 7.05(d, 2H), 7.21(m, 2H), 7.33-7.43(m, 3H); LRMS APCI+ m/z 214 [MH]+
According to the analysis of related databases, 64248-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; WO2006/64336; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts