Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 42872-74-2, name is 3-Bromo-4-methylbenzonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Bromo-4-methylbenzonitrile
2,6-Difluoro-N-[2′-methyl-5′-(4-methyl-thiazol-2-yl)-biphenyl-4-yl]-benzamide A solution of 3-bromo-4-methyl-benzonitrile (500 mg, 2.55 mmol) in ammonia solution (2 M in ethanol, 10 mL) was bubbled with H2S gas slowly for 1 hr. The solution was stirred for 3 hr at room temperature before the nitrogen was bubbled through the solution to remove H2S. The solution was concentrated to give the crude s (450 mg) which was used directly in the next reaction. The solution of s (100 mg, 0.43 mmol) and 1-chloropropan-2-one (200 muL, 2.5 mmol) in ethanol (2 mL) was refluxed at 85 C. for 10 hr. The solvent was removed and column chromatography afforded t (60 mg, 52%). Compound 38 was obtained by a Suzuki coupling reaction analogous to that described for Compound 20. 1H NMR (300 MHz, CDCl3) delta 7.93 (s, 1H), 7.80-7.68 (m, 4H), 7.40-7.29 (m, 4H), 7.03-6.96 (m, 2H), 6.82 (s, 1H), 2.48 (s, 3H), 2.31 (s, 3H); ESMS cacld (C24H18F2N2OS): 420.1; found: 421.1 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Synta Pharmaceuticals Corp.; US2006/173006; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts