Related Products of 26391-06-0,Some common heterocyclic compound, 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, molecular formula is C7H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, 60% NaH (0.35g, 8.8 mmol) was added to solution of 2-cyano-N,N-diethylacetamide (0.56 g, 4.0 mmol) in anhydrous THF (15 mL) at -5 C. The resulting suspension was stirred at-S C for 15mm and the THF solution of 3,4-dimethoxy-5- nitrobenzoyl chloride was added over 10mm and stirred for an additional lh at -5C. The reaction mixture was warmed to 0 C, quenched by the addition of 1N.HC1 solution (4 mL) and stirred for 10mm at room temperature, extracted by ethyl acetate (25 mL X 2), the organic layers was dried with Na2504 and concentrated in vacuo to give the title compound as an orange solid (705 mg, 99%). MS [MH] calcd for C,6H,9N306 350.1, found 350.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyano-N,N-diethylacetamide, its application will become more common.
Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; HUANG, Niu; PENG, Shiming; (87 pag.)WO2016/206573; (2016); A1;,
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