Application of 867366-91-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 867366-91-4, name is 3-Bromo-5-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
3-bromo-5- methoxybenzonitrile (8.3 g, 39.1 mmol),dicyclohexyl(2′,6′-dimethoxy-[l, -biphenyl]-2- yl)phosphine (S-Phos) (1.286 g, 3.13 mmol), phenylboronic acid (5.84 g, 47.0 mmol), Pd2(dba)3 and 200 mL toluene were charged in a flask and refluxed overnight. The reaction was cooled down and 200 mL of ethyl acetate was added. The crude mixture was run though a silica gel plug, and the product was confirmed by GC. After distillation under vacuum, 7.5 g of a white product was obtained.
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-5-methoxybenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; XIA, Chuanjin; YEAGER, Walter; LI, David Zenan; FIORDELISIO, James; MA, Bin; ELSHENAWY, Zeinab; LAYEK, Suman; BARRON, Edward; KOTTAS, Gregg; BROOKS, Jason; WO2012/116231; (2012); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts