These common heterocyclic compound, 21667-62-9, name is 3-(3-Chlorophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-(3-Chlorophenyl)-3-oxopropanenitrile
To 3-chlorobenzoylacetonitrile (24,360 mg, 2 mmol) and sulfur (76 mg) in DMF (4 [N-IL),] triethylamine (0.25mL) is added under stirring. To this solution tetrahydro-4H-pyran-4-one (1,200 mg, 2 mmol) is added dropwise. The mixture is stirred for 16 hours and it is poured into water (30 [ML),] which is extracted with diethyl ether (30 [ML).] The ethereal solution is dried with sodium sulfate and concentrated to give the desired compound as an orange solid (253 mg, 43%). Physical characteristics: MS [(ES+)] for [M/Z] 294,296 (M+H).
The synthetic route of 3-(3-Chlorophenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/35591; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts