Related Products of 6136-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6136-93-2 name is 2,2-Diethoxyacetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 2,2-diethoxyacetonitrile (4.0 g, 30.97 mmol) and sodium methoxide (1.2 mL, 5.4 mol/L, 6.19 mmol) in methyl alcohol (40 mL) was stirred at 25C for 3 hrs, then concentrated to dryness. The residue was taken up in dichloromethane (200 mL) and washed with water (3 x 80 mL) and brine, dried over anhydrous MgS04, filtered and concentrated under vacuum to give methyl 2,2-diethoxyacetimidate (5 g, crude), which was directly used in the next step without purification. LCMS (ESI) [M+H]+ = 162.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyacetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; LIANG, Jun; MENDONCA, Rohan V.; SIU, Michael; TELLIS, John C.; WANG, Weiru; WEI, BinQing; CHAN, Bryan K.; CHOO, Edna F.; DROBNICK, Joy Alison; GAZZARD, Lewis J.; HEFFRON, Timothy; (159 pag.)WO2020/72627; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts