Reference of 2469-99-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2469-99-0 as follows.
General procedure: A mixture of(tetrahydropyran-4-yl)hydrazine (2.32 g, 20 mmol), 3-oxobutyronitrile (1.66 g, 20 mmol) in ethanol (50 mL) was stirred at 90 C for overnight. The reaction was cooled to room temperature and was concentrated. The residue was purified by flash HPLC(MeCN / H20 = 5/100 to 95/100) to afford the desired product 5-methyl-2-(tetrahydropyran-4-yl)-2H-pyrazol-3-ylamine (2.6 g yield: 72%) as white solid. MS: m/z 182.3 (M+H).
According to the analysis of related databases, 2469-99-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; HASSIG, Christian, A.; JACKSON, Michael, R.; ARDECKY, Robert, John; PASS, Ian; (436 pag.)WO2016/123392; (2016); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts