Synthetic Route of 118431-88-2, The chemical industry reduces the impact on the environment during synthesis 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, I believe this compound will play a more active role in future production and life.
3-Cyclopropyl-3-oxopropanenitrile (2.61 g, 24 mmol) and 4-hydrazinylbenzoic acid (3.0 g, 20 mmol) were dissolved in ethanol and the solution was heated at reflux for 12 h. The reaction mixture was concentrated and re-dissolved in methanol (30 mL) followed by addition of CF3CO2H (15 mL). The reaction mixture was stirred at room temperature for 12 h and the volatile components were removed on a rotary evaporator. The remaining residues were washed with ethyl acetate and 4-(5-amino-3-cyclopropyl- 1H-pyrazol-1-yl)benzoic acid was collected by filtration as a solid (6.44 g). ?H NMR (400 MHz, DMSO-d6): 8.02 (d, I = 8.70 Hz, 2H), 7.74 (d, I = 8.70 Hz, 2H), 5.30 (s, 1H), 1.85-1.75 (m, 1H), 0.95-0.85 (m, 2H), 0.73-0.65 (m, 2H). ESI-MS calculated for C,3H,4N302[M+Hj+ = 244.11; Observed: 244.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHAO, Yujun; ZHOU, Bing; AGUILAR, Angelo; (114 pag.)WO2016/138332; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts