Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151-18-8, name is 3-Aminopropanenitrile, A new synthetic method of this compound is introduced below., SDS of cas: 151-18-8
10 (150 mg, 0.37 mmol), l^-dicyclohexylcarbodiimide (76.3 mg, 0.37 mmol) and 1- hydroxybenzotriazole (50 mg, 0.37 mmol) were dissolved in DMF (3 ml) and stirred at 05 0C then 3-aminopropionitrile was added drop wise to the above mixture. After stirring for 10 h at 0 0C then for 14 h at ambient temperature, the reaction mixture was poured into ice- cold H2O and extracted with EtOAc. The combined organic extracts were washed successively with IN HCl, H2O, 8% NaHCO3 solution, H2O and brine. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Purification by silica gel o chromatography (EtOAc, 100%) gave 18a (102.2 mg, 60.2%). 1H NMR (400 MHz, CDCl3) delta 8.41 (t, J- 5.72 Hz, IH), 7.27-7.14 (m, IH), 7.07-7.02 (m, IH), 6.96 (s, IH), 6.29 (s, IH), 5.71 (d, J= 8.17 Hz, IH), 3.99-3.95 (m, IH), 3.60-3.46 (m, 3H), 2.65-2.61 (m, 2H), 2.23 (t, J= 7.76 Hz, 2H), 1.36 (t, J= 7.2 Hz, 2H), 1.25-1.14 (m, 8H), 0.86 (t, J= 7.35 Hz, 3H); 13C NMR (100 MHz, CDCl3) delta 167.57, 162.27, 157.15, 151.61, 148.85, s 132.82, 126.43, 119.17, 117.90, 117.41, 116.24, 113.69, 113.62, 64.51, 35.89, 33.07, 31.50, 29.80, 29.04, 29.00, 28.74, 22.52, 17.99, 13.98.
The synthetic route of 151-18-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2008/54290; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts