Related Products of 332-25-2, The chemical industry reduces the impact on the environment during synthesis 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, I believe this compound will play a more active role in future production and life.
Step 5 N-Hydroxy-4-(trifluoromethoxy)benzimidamide [0365] To a solution of 4-(trifluoromethoxy)benzonitrile (2.0 g, 10.6 mmol) in EtOH (20 mL), TEA (53 g, 53.0 mmol) and NH2OH.HCl (3.6 g, 26.5 mmol) were added in sequence. The mixture was refluxed for 4 h, cooled to RT, and concentrated under reduced pressure. The residue was diluted with H2O (20 mL), and extracted with EtOAc (20 mL×3). The combined organic layers were washed with H2O (1×10 mL) and brine (1×10 mL), dried over Na2SO4, filtered and concentrated to afford the crude N-hydroxy-4-(trifluoromethoxy)benzimidamide (2.0 g, 85percent), which was directly used for next reaction without further purification. MS (ES+) C8H7F3N2O2 requires: 220. found: 221 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center; Jones, Philip; DiFrancesco, Maria Emilia; Petrocchi, Alessia; Marszalek, Joe; Liu, Gang; US2014/57914; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts