Electric Literature of 120315-65-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120315-65-3, name is 4-Bromo-3-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 0.17 mmol lnt2.1 in 1.33 mL NMP was combined with 0.44 mmol 4-Bromo-3-methoxybenzonitrile (48.6 mg, 2.6 eq), 0.04 mmol Pd2(dba)3 (36.6 mg, 0.23 eq), 0.12 mmol rac-BINAP (74.7 mg, 0.7 eq) and 0.25 mmol NaOtBu (24.03 mg, 1.5 eq) in a sealed vial and heated at 170 C under microwave irradiation for 2 h. After cooling, the solution was filtered and subjected to preparative HPLC to give 4.7 mg of the title compound. UPLC-MS: RT = 1.15 min; m/z (ES+) 400.5 [MH+]; required MW = 399.5.
The synthetic route of 4-Bromo-3-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Schering Pharma AG; EP2343297; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts