Synthetic Route of 939-79-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-cyano-2-nitrotoluene (4.0 g, 24.8 mmol) insulfolane (10 mL) was added terephthaldehyde (1.66 g, 12.4 mmol)and piperidine (1.0 g, 12.6 mmol). The resulting mixturewas heatedat 150 C for 45 min, forming an orange precipitate. The reactionwas cooled to 25 C, and diluted with CHCl3 (20 mL). The mixturewas stirred for 30 min at 25 C, then the precipitatewas filtered andrinsed with additional CHCl3 (12 mL). The resulting solids weredried to yield compound 6 (4.1 g) as an orange powder. The orangepowder was added in triethyl phosphite (50 mL). The mixture washeated to reflux for 2 days and then cooled to 25 C, anddichloromethane (50 mL) was added. The suspension was stirredfor 30 min at 25 C, then the solids were filtered and rinsed withadditional CH2Cl2 (20 mL). The resulting solids were dried to yieldcompound 7 (2.1 g, 64%) as gold-yellow powder; 1H NMR (400 Hz,DMSO-d6): d 12.21 (s, 2H), 8.07 (s, 4H), 7.86 (s, 2H), 7.73 (d,J 8.0 Hz, 2H), 7.35 (d, J 8.0 Hz, 2H), 7.19 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 4-Methyl-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Liu, Yonghua; Hu, Xinxin; Wu, Yanbin; Zhang, Weixing; Chen, Xiaofang; You, Xuefu; Hu, Laixing; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 771 – 782;,
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