Reference of 243128-37-2, The chemical industry reduces the impact on the environment during synthesis 243128-37-2, name is 4-Fluoro-3-methoxybenzonitrile, I believe this compound will play a more active role in future production and life.
To a stirred solution of 51 (16.0 g, 105.8 mmol) in dry diethyl ether (1000 mL) at -78 C was added Ti (O?Pr)4 (35.1 mL, 116.3 mmol). EtMgBr (3M soln. in Et20, 70.5 mL, 211.6 mmol) was added dropwise under nitrogen atmosphere to the reaction mixture and stirred at room temperature at for 1 h. BF3.OEt2 (26.5 mL, 211.6 mmol) was added dropwise to the reaction mixture and stirred at room temperature for 1.5 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with iN HC1 and stirred for 10 mm. The reaction mixture was neutralized with aqueous NaOH and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 52. Yield: 8.0 g, 41%. ?HNMR (400 IVIFIz, DMSO-d6) 0.87 -0.92 (m, 4H), 2.33 (br s, 2H) 3.83 (s, 3H), 6.76-6.80 (m, 1 H), 7.02 -7.09 (m, 1H), 7.13 (d, J= 7.83 Hz, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-3-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts