Application of 612-24-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 612-24-8, name is 2-Nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Nitro aromatic (1.0 mmol), B2(OH)4 (5.0 equiv, 5.0 mmol), and H2O (3.0 mL) were added in a10 mL tube. The reaction mixture was stirred at 80 C for 8 h. When the reaction was completemonitored by TLC, the mixture was cooled to room temperature, extracted with ethyl acetate (3 ×20 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gel columnchromatography.
The synthetic route of 2-Nitrobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Danyi; Zhou, Yanmei; Zhou, Haifeng; Liu, Sensheng; Liu, Qixing; Zhang, Kaili; Uozumi, Yasuhiro; Synlett; vol. 29; 13; (2018); p. 1765 – 1768;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts