Related Products of 6330-25-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6330-25-2 name is 2-Cyano-N-methyl-acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
9.6: 7-Amino-2-chloro-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid Methylamide; In a 250 ml round-bottomed flask, under a nitrogen atmosphere, 1.3 g (33.0 mmol) of NaH at 60% are suspended in 35 ml of anhydrous DMF. The temperature of the mixture is reduced to 0 C. by means of an ice bath. 1.6 g (16.5 mmol) of 2-cyano-N-methylacetamide are added and the mixture is then stirred for 15 min at 0 C. and 1 h at ambient temperature. The temperature of the mixture is reduced to 0 C. by means of an ice bath, before said mixture is added dropwise to a solution, at 0 C., of 3.2 g (15.8 mmol) of the compound of stage 9.5 dissolved in 35 ml of DMF. The mixture is stirred for 2 hours at ambient temperature and then 660 mg (16.5 mmol) of NaH at 60% are added. The stirring of the mixture is continued for 2 h at ambient temperature and then the mixture is poured into ice-cold water (50 ml) and the DMF is evaporated off under reduced pressure. The precipitate formed is filtered off and washed with water (2×25 ml) and the resulting product is dried in an oven, so as to obtain 2.3 g (8.4 mmol) of compound in the form of a white powder. Yield=53%. 1H NMR DMSO d6 (300 MHz): 1.23 (t, J=7.1 Hz, 3H); 2.80 (d, J=4.7 Hz, 3H); 4.34 (q, J=7.1 Hz, 2H); 8.42 (bs, 1H); 9.11 (s, 1H); 10.71 (d, J=4.7 Hz, 1H); 11.96 (bs, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N-methyl-acetamide, and friends who are interested can also refer to it.
Reference:
Patent; SANOFI-AVENTIS; US2011/251194; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts