Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Diethyl 2-(2-cyanoethyl)malonate
(a) Diethyl 2-(2-cyanoethyl)-2-(5-nitropyrid-2-yl)malonate Sodium hydride (53% dispersion in oil) (30.71g, 0.66mole) was washed by decantation with xylene (2 * 150ml), ether (150ml), tetrahydrofuran (THF) (150ml) and finally suspended in THF (245ml). Diethyl 2-(2-cyanoethyl) malonate (156g. 0.73mole) in THF (80ml) was added dropwise over 1hr keeping the internal temperature at 18C to 22C (with ice bath cooling). The resulting suspension cleared over 15 minutes when 2-chloro-5-nitropyridine (88.3g, 0.55mole) was added to give a deep magenta solution. The resulting solution was refluxed for 1hr and the solvent was removed on the rotary evaporator. The resulting oil was partitioned between water (500ml) and chloroform (800ml), the pH was adjusted to ~7 (concentrated hydrochloric acid), and the chloroform was run off. The aqueous layer was extracted with a further (2 * 250ml) chloroform, the extracts were combined, dried over magnesium sulphate and the solvent was removed to give an amber oil (~245g). Ether (150ml) was added and the solution was allowed to crystallise to give the title compound (121.98g, 65%), m.p. 59.5-61C. (Found C, 53.7: H, 5.05; N, 12.35%. C15H17N3O6 requires C, 53.75; H, 5.1: N, 12.55%) NM, (CDCl3, 60 MHz); delta 1,37 (6H, t); 2.65 (4H, m); 4.26 (4H, q); 7.84 (1H, dd); 8,49 (1H, dd); 9.32 (1H, dd).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17216-62-5.
Reference:
Patent; SMITH KLINE & FRENCH LABORATORIES, LIMITED; EP287270; (1988); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts