Synthetic Route of 7251-09-4, These common heterocyclic compound, 7251-09-4, name is 4-Amino-2-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(Step 2) A solution of the compound obtained in Step 1 (670 mg, 4.52 mmol) and 3-methylglutaric anhydride (579 mg, 4.52 mmol) in THF (20 mL) was heated with reflux for 14 hr. The reaction solution was concentrated under reduced pressure to give 5-((4-cyano-3-methoxyphenyl)amino)-3-methyl-5-oxopentanoic acid (1.35 g, 4.89 mmol, quantitative) as a brownish-red oil. 1H-NMR(300MHz,DMSO-d6): delta0.75-1.12(3H,m), 1.58-1.91(1H,m), 2.08-2.19(1H,m), 2.22-2.46(2H,m), 2.48-2.55(1H,m), 2.65-2.94(1H,m), 3.36(1H,brs), 3.60(1H,t,J=6.4Hz), 7.25(1H,dd,J=8.3,1.5Hz), 7.45-7.76(2H,m), 10.34(1H,s), 12.11(1H,brs).
Statistics shows that 4-Amino-2-methoxybenzonitrile is playing an increasingly important role. we look forward to future research findings about 7251-09-4.
Reference:
Patent; Takeda Pharmaceutical Company Limited; YAMAMOTO, Satoshi; SHIRAI, Junya; FUKASE, Yoshiyuki; TOMATA, Yoshihide; SATO, Ayumu; OCHIDA, Atsuko; YONEMORI, Kazuko; NAKAGAWA, Hideyuki; EP2759533; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts