Synthetic Route of 218632-01-0, The chemical industry reduces the impact on the environment during synthesis 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
3-((7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7- yl)methyl)amino)-4-nitrobenzonitrile To a light yellow solution of 7-(aminomethyl)-7-((benzyloxy)methyl)-3-(4-methoxybenzyl)- 1-oxa-3-azaspiro[4.5]decan-2-one (4.27 g, 10.1 mmol) in MeCN (67.1 mL) was added potassium carbonate (2.78 g, 20.1 mmol) and 3-fluoro-4-nitrobenzonitrile (2.51 g, 15.1 mmol). the reaction was stirred at rt. After stirring 15 h, the reaction was filtered through a frit. The collected inorganics were washed with DCM/EtOAc. The filtrate was concentrated onto florisil and purified on a 80 g silica gel column (20 – 55 % EtOAc/hexanes, 30 min gradient; 55 % EtOAc/hexanes, 5 min.; 60 mL/min elution; 254 nm detection) to provide the title compound (5.02 g, 83 % yield) as a reddish-orange oil. MS (m/z) 571.0 (M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; BROOKS, Carl; CHEUNG, Mui; EIDAM, Hilary, Schenck; GOODMAN, Krista, B.; HAMMOND, Marlys; HILFIKER, Mark, A.; PATTERSON, Jaclyn, R.; STOY, Patrick; YE, Guosen; WO2012/174342; (2012); A1;,
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