In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2469-99-0, name is 3-Oxobutanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H5NO
3-Oxobutyronitrile (5.04, 1.05 eq) and potassium t-butoxide (7 g, 1.05 eq) were added to DMSO (80 mL).Stir at room temperature for 10 minutes, add (E)-3-penten-2-one (5 g, 1 eq), stir at room temperature for half an hour.Further potassium t-butoxide (7 g, 1.05 eq) was added, and after 1 hour, it was stirred with air overnight. The reaction solution was cooled to 0 C.Diluted with 20 ml of water, 4N HCl (15 ml) was added dropwise, stirred for 15 minutes, filtered to give a solid, which was washed with 100 ml of water to give product g (3.8 g).No further purification is required.
The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Hefei Matter Sciences Institute; Liu Qingsong; Liu Jing; Lv Fengchao; Hu Chen; Wang Wenliang; Wang Aoli; Qi Ziping; Liang Xiaofei; Wang Wenchao; Ren Tao; Wang Beilei; Wang Li; (56 pag.)CN108314677; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts