In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-20-6, name is 4-Chlorobutyronitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 628-20-6
K2CO3 663.40g (4.8mol), KI 26.60g (0.16mol),1-(2-methoxy-phenyl)piperazine hydrochloride 457.40 g (2.0 mol),After adding 1500 mL of acetonitrile, 52.70 g (2.4 mol) of 4-chlorobutyronitrile was added dropwise with stirring at 70 C, and after 44.5 h of reaction, the reaction was completed on the spot plate. stop,In order to avoid solid precipitation of [4-(2-methoxyphenyl) piperazinyl]butyronitrile,The mixture was washed with hot water, and the solid was washed well with acetonitrile.Wash the solid slightly with a mixed solvent of acetone and petroleum ether.The mother liquor is evaporated to dryness and then recrystallized with a small amount of acetone petroleum ether.A total of 466.8 g of a white solid was obtained in a total of 90.0% yield.
The synthetic route of 628-20-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Jin; Yang Rifang; Song Rui; Wu Ning; Li Yunfeng; Wang Weina; Song Dake; (26 pag.)CN109419802; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts