Related Products of 21883-13-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21883-13-6, name is 4-Methoxy-2-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 235 Isomers; N-(3, 4-difluorophenyl)-3-methyl-L-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide andN-(3, 4-difluorophenyl)-3-methyl-D-valyl-(4R)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-4-((9-methoxy-4-methyl-3,4-dihydro-2H-[1,4]oxazino[3,2-c]isoquinolin-6-yl)oxy)-L-prolinamide; Example 235; Preparation of Compounds 235A and 235B; Step 1; 4-methoxy-2-methylbenzonitrile (50 g, 340 mmole) and NBS (62 g, 350 mmole) were suspended in CCl4 (500 ml) and AIBN (5 g, 10% wt) was added. The mixture was heated at flux overnight. Filtered off precipitate and removed the solvent. The brown oil was purified by flash column (2-5% acetone:hexanes). White crystal (36 g) were obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxy-2-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bristol-Myers Squibb Company; US2008/119461; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts