70484-01-4, name is 4-Bromophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Bromophthalonitrile
A stirrer,thermometer,condenser,A 100 mL four-necked glass flask equipped with a glass stopper was purged with nitrogen,The open end of the condenser was sealed with a gentle stream of nitrogen. Bis (dibenzylideneacetone) platinum (0) (6.6 mg, 0.01 mmol),4-Bromophthalonitrile (207 mg, 1.0 mmol) and N-methylpyrrolidone (4 mL) were charged,The flask contents were stirred at room temperature to dissolve the solids. Triethylamine (304 mg,3.0 mmol) was added,1, 1, 1, 3, 5, 5, 5-heptamethyltrisiloxane (178 mg, 0.8 mm pl) was slowly added and stirred at 19 to 22 C for 17 hours. Bis (dibenzylideneacetone) platinum (0) (6.6 mg, 0.01 mmol) was added,1,1,1,3,5,5,5-heptamethyltrisiloxane (178 mg, 0.8 mm pl)Was added slowly and stirring was continued at 19 to 22 C. for 12 hours. By gas chromatography mass spectrometry (GC-MS) of the reaction mixture,Formation of the target compound was confirmed.
The synthetic route of 70484-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIN-ETSU CHEMICAL COMPANY LIMITED; KIYOMORI, AYUMU; ITOH, YUSUKE; (49 pag.)JP2015/10084; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts