Some common heterocyclic compound, 6587-24-2, name is Methyl 2-cyanobenzoate, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6587-24-2
To a solution of methyl 2-cyanobenzoate (322 mg, 2.0 mmol)) in MeOH (6 mL), Pd/C (10% by weight, 61 mg) and 4.0 N HCl in dioxane (0.875 mL, 1.75 eq) were added. This mixture was hydrogenated with a H2 balloon for 2.0 h. After filtration and concentration, 23A was obtained as HCl salt. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.86 (s, 3 H) 4.30 (d, J=5.71 Hz, 2 H) 7.55 (m, 1 H) 7.65 (m, 2 H) 7.99 (d, J=7.91 Hz, 1 H) 8.49 (s, 3 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6587-24-2, its application will become more common.
Reference:
Patent; Bristol-Myers Squibb Company; US2007/3539; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts