Related Products of 90401-84-6,Some common heterocyclic compound, 90401-84-6, name is 6-Cyano-1-tetralone, molecular formula is C11H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
alpha”l ) delta-Hvdroxy-delta-d-trityl-I H-imidazol^-vD-delta.thetaJ.S-tetrahydronaphthalene^-carbonitrile 12 mmol of ethylmagnesium chloride (3M in diethyl ether) are added to a solution of 10 mmol of 4-iodo-1-trityl-1 H-imidazole [96797-15-8] in 40 ml of dichloromethane. The mixture is stirred for 45 minutes, and a solution of 10 mmol of 5-oxo-5,6,7,8-tetrahydronaphthalene- 2-carbonitrile [90401-84-6] in 15 ml of dichloromethane is added. The reaction mixture is stirred at room temperature overnight and quenched with saturated ammonium chloride solution. The phases are separated, and the aqueous phase is extracted with dichloromethane (3x). The combined organic phases are washed with brine, dried with sodium sulphate and evaporated. The title compound is identified from the residue on the basis of the Rf by flash chromatography (SiO2 60F).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Cyano-1-tetralone, its application will become more common.
Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2007/116098; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts