Electric Literature of 177476-76-5, These common heterocyclic compound, 177476-76-5, name is 4-Amino-3-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Amino-3-methoxybenzonitrile (5.93 g, 40 mmol), acetic acid (40 mL) and methanol (100 mL) were added to a 250 mL single neck flask, then bromine (7.03 g, 44 mmol) was added dropwise at 0C. The reaction mixture was stirred for 2 h at rt. To the mixture was added saturated aqueous sodium carbonate (200 mL). The mixture was extracted with ethyl acetate (100 mL x 2). The combined organic phases were washed with saturated brine (100 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate/petroleum ether (v/v) = 1/10) to give the title compound as a pale yellow solid (7.63 g, 84%).MS (ES-API, pos. ion) m/z: 227.9 [M + 2]t
Statistics shows that 4-Amino-3-methoxybenzonitrile is playing an increasingly important role. we look forward to future research findings about 177476-76-5.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; YANG, Xinye; HUANG, Changwei; MA, Facheng; ZHANG, Ji; WANG, Xiaojun; ZHANG, Yingjun; (162 pag.)WO2017/36404; (2017); A1;,
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