19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-(3-Methoxyphenyl)acetonitrile
Example 1 Synthesis of Exemplified Compound 4 (A) Synthesis of Compound 4-a In a nitrogen atmosphere, 15.5 g of metallic sodium, 200 ml of 1-methyl-2-pyrrolidinone (NMP), and 66.8 g of diphenyldisulfide (PhSSPh) were placed into a flask, and the mixture was refluxed under heating at an outside temperature of 200 C. for 30 minutes. Thereto, added was a solution prepared by dissolving 75 g of (3-methoxyphenyl)acetonitrile in 200 ml of 1-methyl-2-pyrrolidinone, while being refluxed at the same temperature, followed by refluxing under heating at an outside temperature of 200 C. for additional 3 hours. After completion of the reaction,the reaction liquid was cooled to room temperature (r.t.), and 200 ml of hexane and 400 ml of a 0.5M aqueous sodium hydroxide solution were added thereto. The resultant mixture was stirred and transferred into a separatory funnel, and the resultant hexane layer was separated and removed. To the obtained aqueous layer, was added 3M hydrochloric acid to adjust the solution to be acidic, and was subjected to extraction by ethyl acetate. The solution was separated, and an ethyl acetate layer was obtained. The ethyl acetate layer was washed with 1M hydrochloric acid and then a saturated saline solution, dried over anhydrous magnesium sulfate, followed by distilling off the solvent, and being purified by silica gel column chromatography, to thereby obtain 70.4 g (100% yield) of Compound 4-a. 1H NMR (300 MHz, CDCl3) ? (ppm): 3.73 (2H, s), 6.16 (1H, s), 6.80 to 6.89 (3H, m), 7.20 to 7.30 (1H, m)
The synthetic route of 19924-43-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUJI PHOTO FILM CO., LTD.; US2006/142553; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts