Electric Literature of 54454-12-5, The chemical industry reduces the impact on the environment during synthesis 54454-12-5, name is 3-Chloro-2-methylbenzonitrile, I believe this compound will play a more active role in future production and life.
General Method A for the synthesis of hydroxyamidines (A-4) To a solution of nitrile-derivative (1 .0 eq.) in MeOH (0.5 M), hydroxylamine HCI (1 .1 to 3.0 eq.) and NaHC03 (1 .1 to 3.0 eq.) was added at rt. The resulting suspension was stirred at a given temperature and time (see Table 3). The mixture was concentrated in vacuo, then EtOAc was added to the remaining residue and the org. layer was washed with brine (1x), dried (MgS04), filtered and concentrated to yield hydroxyamidine A-4.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2014/57435; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts