Electric Literature of 16588-02-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16588-02-6, name is 2-Chloro-5-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-chloro-5-nitrobenzonitrile (1 g, 5.49 mmol) and 3,5- difluorobenzenethiol (960 mg, 6.6 mmol) in DIVIF (20 mL) was added K2C03 (2.3 g, 16 mmol). The reaction was stirred at 80 C overnight. The residue was poured into H20 (20 mL) and the aqueous phase was extracted with EA (30 mL x2). The organic layer was washed with brine (20 mL), dried over Na2SO4 and concentrated. The residue was purified by silica gel column (PE/EA = 10/1) to give 2-((3,5-difluorophenyl)thio)-5-nitrobenzonitrile (620 mg, yield: 39%) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts