Reference of 1897-52-5,Some common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,6-Difluorobenzonitrile (2.78 g, 20.0 mmol) and 3-(trifluoromethyl)phenol (3.89 g, 24.0 mmol) were dissolved in DMF(20 mL) and K2CO3 (8.29 g, 60 mmol) was then addedand the resulting mixture was heated at 100C for 16 h.After cooling to room temperature, the mixture was subjectedto EtOAc:water extraction and the organic layer wasthen separated, washed with 1 N NaOH and then with 10%aqueous K2CO3, dried (MgSO4), and evaporated to get2-fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile (5.23 g,93% yield).
The synthetic route of 1897-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Note; Bepary, Sukumar; Yoon, In Kwon; Lee, Ge Hyeong; Bulletin of the Korean Chemical Society; vol. 37; 12; (2016); p. 2054 – 2057;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts