In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4640-66-8 as follows. name: 4-Chlorophenacylcyanide
General procedure: To a 25 mL flask was added catalysts 5g (0.04 mmol, 23.7 mg), K2CO3 (0.24 mmol, 33.2 mg), 3 or 6 or 8 (0.24 mmol) and toluene (1.5 mL). After the mixture was stirred at 0 C for 5 min, a solution of 2 (0.20 mmol) in toluene (1.5 mL) was slowly added. The reaction was stirred at 0 C for 48 h. After that, the solvent was removed and the residue was directly subjected to silica gel column chromatography (petroleum ether/ethyl acetate as eluent) to give (3+3) annulation product.
According to the analysis of related databases, 4640-66-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ni, Chunjie; Zhou, Weiping; Tong, Xiaofeng; Tetrahedron; vol. 73; 24; (2017); p. 3347 – 3354;,
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