Related Products of 2182-39-0,Some common heterocyclic compound, 2182-39-0, name is 2-(Phenylamino)propanenitrile, molecular formula is C9H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
F. 2-(2-Methoxy-4-methyl-7-quinolylmethyl)-3-anilinoacrylonitrile. To a stirred mixture of 0.65 g (3.20 mM) of 2-methoxy-4-methyl-7-quinolinecarbaldehyde and 0.52 g (3.50 mM) of anilinopropionitrile in 10 mL of dry dimethyl sulfoxide was added in one portion 0.19 g (3.50 mM) of sodium methoxide. The resultant mixture was then heated to 90-95 C. (internal temperature) for 2 h., after which the dimethyl sulfoxide was removed in vacuo. Addition of distilled water to the resultant concentrate resulted in a brown precipitate. This was filtered, washed repeatedly with water and air-dried. Recrystallization from absolute ethanol resulted in 0.49 g (46%) of 2-(2-methoxy-4-methyl-7-quinolylmethyl)-3-anilinoacrylonitrile as a light brown solid: mp 170-172 C. Anal. Calcd. for C21 H19 N3 O: C, 76.57; H, 5.81; N, 12.76. Found: C, 76.34; H, 5.83; N, 12.60.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Phenylamino)propanenitrile, its application will become more common.
Reference:
Patent; Burroughs Wellcome Co.; US4587341; (1986); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts