Related Products of 4435-14-7,Some common heterocyclic compound, 4435-14-7, name is 2-Cyclohexylacetonitrile, molecular formula is C8H13N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step (2) Preparation of 4-[(3-Benzofuranyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-Oxide According to Scheme I illustrated by Example 4, 3-benzofuranylacetonitrile was converted to the desired product as beige crystals, m.p. 138.5-140 C. temperature. Cyclohexylacetonitrile (14.7 g, 120 mmol) was added in one portion and the resulting mixture was heated to reflux for 12 hours. The mixture was cooled to room temperature and concentrated to give a yellow solid. The solid was collected by filtration, washed with water, EtOAc/hexane (2:8), and dried in vacuo to give 7.4 g (40%) of the product of sufficient purity for use in the next reaction. NMR (DMSO-d6, 200 MHz): delta 0.85 (m, 2H), 1.10 (m, 3H), 1.64 (m, 6H), 1.80 (d, J=7.0, 2H), 5.25 (br s, 2H), 8.30 (br s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Cyclohexylacetonitrile, its application will become more common.
Reference:
Patent; American Home Products Corporation; US4895860; (1990); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts