Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53312-80-4, name is 4-Amino-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H5FN2
To a stirred solution of 4-amino-2-fluorobenzonitrile (5 g, 36.8 mmol, 1 eq) in H2O (200 mL) chloroform (50 mL) mixture was added thiophosgene (3 mL, 40.4 mmol, 1.1 eq) slowly and the mixture was stirred at RT for 5 h. The reaction was monitored by TLC. After completion, the reaction mixture was diluted with water (300 mL) and extracted with DCM (200 mL c 3). The combined organic layers were washed with water (200 mL), brine (200 mL), dried over NaaSCfi, filtered and concentrated under reduced pressure to afford the title compound. Analytical data: ‘H NMR (400 MHz, DMSO-c/r,) d 8.02 (t, J = 7.9 Hz, 1H), 7.76 (dd, J= 10.3, 1.5 Hz, 1H), 7.44-7.53 (m, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NUVATION BIO INC.; PETTIGREW, Jeremy D.; CHAKRAVARTY, Sarvajit; PHAM, Son Minh; CHEN, Jiyun; KANKANALA, Jayakanth; NAYAK, Anjan Kumar; BARDE, Anup; PUJALA, Brahmam; (108 pag.)WO2020/113088; (2020); A1;,
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